The Cougars scored on their first drive. Saints defensive tackle Corey Hardy helped to temporarily stave off further damage by recovering a fumble.
But Goodpasture piled up 22 unanswered points in the second quarter.
The teams traded touchdowns in the second half. Running back/wide receiver Eli Wilson had both Saints scores.
Mt. Juliet Christian will play host to Holy Rosary at 6 p.m. Thursday at Suey Field.